[The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].
In: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), Jg. 60 (2014), Heft 4, S. 97-104
academicJournal
Zugriff:
As a result of resistance test to hypoxia of Drosophilas melanogaster of Oregon strain, we identified a high resistance (Group II) and low resistance (Group III) subpopulations of flies. Flies from groups II and III were incubated in a constant normobaric hypoxia (Po2=62-64 mm Hg) for 10 generations. A highly resistant group (Group IV) were exposed to a shortterm anoxia (Po,=1,5 mm Hg, 5 min) every generation. Larvae from Groups II, III, and IV demonstrated significantly elevated levels of Sir and CG 14740 expression. Larvae from Group II had a significantly higher expression of CG 14740 compared to group III. The restitution time after exposure to anoxia was significantly reduced in Group II (on 31% of the control values) Our results suggest that long-term adaptation to low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.
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[The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].
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Autor/in / Beteiligte Person: | VIa, Berezovs'kyĭ ; Chaka, OH ; Litovka, IH ; Levashov, MI ; Ianko, RV |
Zeitschrift: | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), Jg. 60 (2014), Heft 4, S. 97-104 |
Veröffentlichung: | Kyiv : Naukova Dumka ; <i>Original Publication</i>: Kyïv : Nauk. dumka, 1994-, 2014 |
Medientyp: | academicJournal |
ISSN: | 2522-9028 (print) |
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