[Influence of tissue-specific superoxide dismutase genes expression in brain cells on Drosophila melanogaster sensitivity to oxidative stress and viability].

Vitushynska, MV ; Matiytsiv, NP ; et al.

In: TSitologiia i genetika, Jg. 49 (2015-03-01), Heft 2, S. 21-8

academicJournal

The study has shown that both functional gene knockout Sodl and Sod2 and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress (OS) conditions. The lowest survival rate was only 20.5% in insects with Sod2 knockout in neurons. Comparative analysis of the survival curves showed that adults with altered tissue-specific expression of the studied genes had reduced average and maximum life span. Under OS conditions induced by 5% hydrogen peroxide the life spans of wild type Oregon R and transgenic insects were significantly reduced. Altered Sod gene expression in glial tissue leads to degenerative changes in Drosophila brain at the young age. During the aging of insects and the action of pro-oxidants increasing of neurodegenerative phenotype is observed.

Titel:	[Influence of tissue-specific superoxide dismutase genes expression in brain cells on Drosophila melanogaster sensitivity to oxidative stress and viability].
Autor/in / Beteiligte Person:	Vitushynska, MV ; Matiytsiv, NP ; Chernyk, Y
Zeitschrift:	TSitologiia i genetika, Jg. 49 (2015-03-01), Heft 2, S. 21-8
Veröffentlichung:	Kiev : Izdatelstvo Naukova Dumka ; <i>Original Publication</i>: Kiev., 2015
Medientyp:	academicJournal
ISSN:	0564-3783 (print)
Schlagwort:	Aging drug effects Animals Animals, Genetically Modified Brain cytology Brain drug effects Brain growth & development Drosophila Proteins Drosophila melanogaster drug effects Drosophila melanogaster growth & development Drosophila melanogaster metabolism Gene Expression Regulation, Developmental Hydrogen Peroxide pharmacology Longevity drug effects Longevity genetics Neuroglia cytology Neuroglia drug effects Neurons cytology Neurons drug effects Organ Specificity Oxidative Stress Signal Transduction Superoxide Dismutase deficiency Superoxide Dismutase-1 Aging genetics Brain metabolism Drosophila melanogaster genetics Neuroglia metabolism Neurons metabolism Superoxide Dismutase genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Ukrainian Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: Ukrainian [Tsitol Genet] 2015 Mar-Apr; Vol. 49 (2), pp. 21-8. MeSH Terms: Aging / genetics ; Brain / metabolism ; Drosophila melanogaster / genetics ; Neuroglia / metabolism ; Neurons / metabolism ; Superoxide Dismutase / genetics ; Aging / drug effects ; Animals ; Animals, Genetically Modified ; Brain / cytology ; Brain / drug effects ; Brain / growth & development ; Drosophila Proteins ; Drosophila melanogaster / drug effects ; Drosophila melanogaster / growth & development ; Drosophila melanogaster / metabolism ; Gene Expression Regulation, Developmental ; Hydrogen Peroxide / pharmacology ; Longevity / drug effects ; Longevity / genetics ; Neuroglia / cytology ; Neuroglia / drug effects ; Neurons / cytology ; Neurons / drug effects ; Organ Specificity ; Oxidative Stress ; Signal Transduction ; Superoxide Dismutase / deficiency ; Superoxide Dismutase-1 Substance Nomenclature: 0 (Drosophila Proteins) ; BBX060AN9V (Hydrogen Peroxide) ; EC 1.15.1.1 (Superoxide Dismutase) ; EC 1.15.1.1 (Superoxide Dismutase-1) ; EC 1.15.1.1 (superoxide dismutase 2) Entry Date(s): Date Created: 20150603 Date Completed: 20150611 Latest Revision: 20161125 Update Code: 20231215

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