Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index.
In: Cancer epidemiology, Jg. 54 (2018-06-01), S. 75-81
Online
academicJournal
Background: Despite advances in the management of nephroblastoma (Wilms' tumor, WT), the etiology of the tumor remains obscure. We aimed to compare nephroblastoma incidence rates and time trends among children (0-14 years) in 12 Southern and Eastern European (SEE) countries and the Surveillance, Epidemiology, and End Results Program (SEER), USA, in relation to the human development index (HDI).
Methods: In total 1776 WT cases were recorded in 13 SEE collaborating registries (circa 1990-2016), whereas data on 2260 cases (1990-2012) were extracted from the SEER database. Age-standardized incidence rates (AIRs) were calculated and correlated with HDI, whereas temporal trends were evaluated using Poisson regression and Joinpoint analyses.
Results: The overall SEE AIR (9.2/10 6 ) was marginally higher than that of the SEER (8.3/10 6 ), whereas significant differences were noted among the 13 SEE registries which comprised mainly Caucasian populations. A statistically significant temporal increase in incidence was noted only in Belarus. Most cases (∼75%) were diagnosed before the fifth year of life, with rates steadily declining thereafter; median age at diagnosis was similar in SEE countries and SEER. A slight male preponderance in the first year of life (male:female = 1.1) was followed by a female preponderance in the older age groups (male:female = 0.7). Lastly, a statistically significant positive association between higher HDI and increasing nephroblastoma incidence was noted (regression coefficient: +3.25, 95%CI: +1.35, +5.15).
Conclusions: Variations in incidence and time trends across the examined registries, changing male-to-female patterns with advancement in age, and positive associations with the HDI imply a plausible role for environmental and genetic factors in disease etiology, and these need to be explored further.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
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Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index.
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Autor/in / Beteiligte Person: | Doganis, D ; Panagopoulou, P ; Tragiannidis, A ; Georgakis, MK ; Moschovi, M ; Polychronopoulou, S ; Rigatou, E ; Papakonstantinou, E ; Stiakaki, E ; Dana, H ; Bouka, E ; Antunes, L ; Bastos, J ; Coza, D ; Demetriou, A ; Agius, D ; Eser, S ; Ryzhov, A ; Sekerija, M ; Trojanowski, M ; Zagar, T ; Zborovskaya, A ; Perisic, SZ ; Stefanaki, K ; Dessypris, N ; Petridou, ET |
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Zeitschrift: | Cancer epidemiology, Jg. 54 (2018-06-01), S. 75-81 |
Veröffentlichung: | Amsterdam : Elsevier, 2018 |
Medientyp: | academicJournal |
ISSN: | 1877-783X (electronic) |
DOI: | 10.1016/j.canep.2018.03.012 |
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