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Different allelic variants of genes that encode ATP-sensitive potassium (K ATP ) channels' subunits may contribute to the development of heart failure. The purpose of the work to investigate SNPs in genes that encode K ATP channels in relation to echocardiographic parameters in chronic heart failure (CHF) patients. Ninety-nine people with CHF of ischemic origin with left ventricular systolic dysfunction were examined. The control group is represented by 108 clinically healthy subjects. KCNJ11 polymorphisms Ile337Val and Glu23Lys, and ABCC8 polymorphism Ser1369Ala were genotyped using polymerase chain reaction. In CHF patients, the frequency of the Ile337Val genotype was: Ile/Ile, 40.4%; Ile/Val, 45.5%; and Val/Val, 14.1%. The patients with the Val/Val genotype had left ventricular (LV) mass that was 334.15 g, which was 27.3% (P < 0.05) lower versus Ile/Val patients (425.48 g). The index of this parameter was also significantly lower (28.4%, P < 0.05). In CHF patients, the frequency of Glu23Lys and Ser1369Ala was: Glu/Glu and Ser/Ser, 43.4%; heterozygote, 44.4%; Lys/Lys and Ala/Ala, 12.2%. The patients with the Lys/Lys and Ala/Ala genotypes had a significantly lower LV mass index and LV end-diastolic volume (22.9% and 26.8%, P < 0.05) versus heterozygotes. Thus, the greatest LV mass and LV end-diastolic volume values are associated with heterozygotes, while the smallest are associated with minor homozygotes.

Titel:	Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP-sensitive potassium channels subunits in the Ukrainian population.
Autor/in / Beteiligte Person:	Strutynskyi, RB ; Voronkov, LG ; Nagibin, VS ; Mazur, ID ; Stroy, D ; Dosenko, VE
Link:	Full Text Finder (Volltext)
Zeitschrift:	Annals of human genetics, Jg. 82 (2018-09-01), Heft 5, S. 272-279
Veröffentlichung:	<2010-> : Oxford : Wiley-Blackwell ; <i>Original Publication</i>: Oxford : Blackwell, 2018
Medientyp:	academicJournal
ISSN:	1469-1809 (electronic)
DOI:	10.1111/ahg.12250
Schlagwort:	Aged Alleles Case-Control Studies Female Gene Frequency Genotype Heart Failure diagnosis Humans Male Middle Aged Ukraine Ventricular Dysfunction, Left genetics Echocardiography Heart Failure genetics Potassium Channels, Inwardly Rectifying genetics Sulfonylurea Receptors genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Ann Hum Genet] 2018 Sep; Vol. 82 (5), pp. 272-279. <i>Date of Electronic Publication: </i>2018 Jul 13. MeSH Terms: Echocardiography* ; Heart Failure / genetics ; Potassium Channels, Inwardly Rectifying / genetics ; Sulfonylurea Receptors / *genetics ; Aged ; Alleles ; Case-Control Studies ; Female ; Gene Frequency ; Genotype ; Heart Failure / diagnosis ; Humans ; Male ; Middle Aged ; Ukraine ; Ventricular Dysfunction, Left / genetics References: Bienengraeber, M., Olson, T. M., Selivanov, V. A., Kathmann, E. C., O'Cochlain, F., Gao, F., ... Terzic, A. (2004). ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nature Genetics, 36, 382-387. https://doi.org/10.1038/ng1329. ; Chutkow, W. A., Simon, M. C., Le Beau, M. M., & Burant, C. F. (1996). 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Contributed Indexing: Keywords: Chronic heart failure; echocardiography; rs5215; rs5219; rs757110 Substance Nomenclature: 0 (ABCC8 protein, human) ; 0 (Kir6.2 channel) ; 0 (Potassium Channels, Inwardly Rectifying) ; 0 (Sulfonylurea Receptors) Entry Date(s): Date Created: 20180714 Date Completed: 20190722 Latest Revision: 20210614 Update Code: 20240513

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Changes of the echocardiographic parameters in chronic heart failure patients with Ile337val, Glu23lys, and Ser1369ala polymorphisms of genes encoding the ATP-sensitive potassium channels subunits in the Ukrainian population.