PREVALENCE OF HEALTHCARE-ASSOCIATED CERVICITIS AND ANTIMICROBIAL RESISTANCE OF THE RESPONSIBLE PATHOGENS IN UKRAINE: RESULTS OF A MULTICENTER STUDY (2019-2021).

Salmanov, AG ; Koctjuk, IM ; et al.

In: Wiadomosci lekarskie (Warsaw, Poland : 1960), Jg. 75 (2022), Heft 9 pt 2, S. 2189-2197

academicJournal

Objective: The aim: To obtain the first estimates of the current prevalence of healthcare-associated cervicitis (HACs) and antimicrobial resistance of responsible pathogens in Ukraine.

Patients and Methods: Materials and methods: We conducted a retrospective multicentre cohort study was based on surveillance data from January 1st, 2019 to December 31st, 2021 in Ukraine. Antibiotic susceptibility testing was determined by Kirby-Bauer disc diffusion test according to the protocol of the European Committee on Antimicrobial Susceptibility Testing.

Results: Results: Of the 6,885 participants in this study, 1746 women (25.5%) met the clinical definition of cervicitis. Prevalence of HACs and cervcits caused sexually transmitted pathogens were 12.7% and 8.3%, respectively. The incidence of HACs among women with a history of gynecological procedures was 25.4%. The main causes of HACs were legal induced abortions (28.8%), vaginal hysterectomy (23.9%), and postpartum instrumental examination (12.8%). The predominant pathogens of HACs were: Escherichia coli, Enterobacter spp., Klebsiella spp., Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis. Methicillin-resistance was observed in 20.8% of S. aureus (MRSA). Vancomycin resistance was observed in 7.4% of isolated enterococci (VRE). Resistance to third-generation cephalosporins was observed in 13.1% Klebsiella spp. and E.coli 17.5% isolates. Carbapenem resistance was identified in 11.6% of P.aeruginosa isolates. The prevalence of ESBL production among E. coli isolates was significantly higher than in K. pneumoniae (33.5%, vs 8.7%). The overall proportion of extended spectrum beta-lactamases (ESBL) production among Enterobacteriaceae was 34.6%.

Conclusion: Conclusions: This study showed that the prevalence of healthcare-associated cervicitis in Ukraine is high, and many cases were caused by antibiotic-resistant pathogens.

Titel:	PREVALENCE OF HEALTHCARE-ASSOCIATED CERVICITIS AND ANTIMICROBIAL RESISTANCE OF THE RESPONSIBLE PATHOGENS IN UKRAINE: RESULTS OF A MULTICENTER STUDY (2019-2021).
Autor/in / Beteiligte Person:	Salmanov, AG ; Koctjuk, IM ; Ihnatieva, OK ; Vitiuk, AD ; Artyomenko, V ; Paliga, I ; Suslikova, LV
Zeitschrift:	Wiadomosci lekarskie (Warsaw, Poland : 1960), Jg. 75 (2022), Heft 9 pt 2, S. 2189-2197
Veröffentlichung:	Konstancin Jeziorna : Aluna Publishing ; <i>Original Publication</i>: Warszawa : Pánstwowy Zakład Wydawnictw Lekarskich, [1960-, 2022
Medientyp:	academicJournal
ISSN:	0043-5147 (print)
DOI:	10.36740/WLek202209202
Schlagwort:	Pregnancy Female Humans Staphylococcus aureus Drug Resistance, Bacterial Escherichia coli Prevalence Cohort Studies Ukraine epidemiology Klebsiella pneumoniae Pseudomonas aeruginosa Delivery of Health Care Anti-Bacterial Agents pharmacology Anti-Bacterial Agents therapeutic use Uterine Cervicitis drug therapy Uterine Cervicitis epidemiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Multicenter Study; Journal Article Language: English [Wiad Lek] 2022; Vol. 75 (9 pt 2), pp. 2189-2197. MeSH Terms: Anti-Bacterial Agents* / pharmacology ; Anti-Bacterial Agents* / therapeutic use ; Uterine Cervicitis* / drug therapy ; Uterine Cervicitis* / epidemiology ; Pregnancy ; Female ; Humans ; Staphylococcus aureus ; Drug Resistance, Bacterial ; Escherichia coli ; Prevalence ; Cohort Studies ; Ukraine / epidemiology ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; Delivery of Health Care Contributed Indexing: Keywords: Ukraine; antimicrobial resistance; healthcare-associated cervicitis; pelvic inflammatory disease; prevalence; risk factors Substance Nomenclature: 0 (Anti-Bacterial Agents) Entry Date(s): Date Created: 20221115 Date Completed: 20221118 Latest Revision: 20221118 Update Code: 20231215

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