Age-Related Changes in the Phospholipase D-Dependent Signal Pathway of Insulin in the Rat Neocortex.
In: Neurophysiology, Jg. 45 (2013-03-01), Heft 2, S. 120-127
Online
academicJournal
Zugriff:
Insulin participates in stabilization of normal functioning of the CNS; phospholipase D (PLD) is an integral part of the signal cascade of this hormone. With age, the lipid spectrum of the cells is modified, which implicates dysfunction of different signal pathways, including that of insulin. In our study, we found that the contents of ceramides and free fatty acids in the neocortex of old (24 months) rats are appreciably higher than that in 3-month-old animals. Under such conditions, the ability of insulin to activate PLD sharply drops. Incubation of neocortical tissues obtained from young animals in the presence of exogenous С2 ceramide or palmitic acid (a precursor of sphingolipids) leads to an increase in the content of endogenous ceramides. This process is accompanied by suppression of the insulinstimulated formation of phosphatidylethanol (PET, a product of reaction of transphosphatidylation of ethanol by PLD). Thus, the obtained data indicate that the activity of a PLD-dependent link of the signal cascade of insulin in the neocortex is significantly weakened with aging; ceramide plays an important role in this process. [ABSTRACT FROM AUTHOR]
Copyright of Neurophysiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Age-Related Changes in the Phospholipase D-Dependent Signal Pathway of Insulin in the Rat Neocortex.
|
---|---|
Autor/in / Beteiligte Person: | Babenko, N. ; Kharchenko, V. |
Link: | |
Zeitschrift: | Neurophysiology, Jg. 45 (2013-03-01), Heft 2, S. 120-127 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0090-2977 (print) |
DOI: | 10.1007/s11062-013-9346-9 |
Schlagwort: |
|
Sonstiges: |
|