Comparison of clinical outcomes and prognostic utility of risk stratification tools in patients with therapy-related vs de novo myelodysplastic syndromes: a report on behalf of the MDS Clinical Research Consortium
In: Leukemia, Jg. 31 (2017-01-23), S. 1391-1397
Online
unknown
Zugriff:
While therapy-related (t)-myelodysplastic syndromes (MDS) have worse outcomes than de novo MDS (d-MDS), some t-MDS patients have an indolent course. Most MDS prognostic models excluded t-MDS patients during development. The performances of the International Prognostic Scoring System (IPSS), revised IPSS (IPSS-R), MD Anderson Global Prognostic System (MPSS), WHO Prognostic Scoring System (WPSS) and t-MDS Prognostic System (TPSS) were compared among patients with t-MDS. Akaike information criteria (AIC) assessed the relative goodness of fit of the models. We identified 370 t-MDS patients (19%) among 1950 MDS patients. Prior therapy included chemotherapy alone (48%), chemoradiation (31%), and radiation alone in 21%. Median survival for t-MDS patients was significantly shorter than for d-MDS (19 vs 46 months, P
| Titel: |
Comparison of clinical outcomes and prognostic utility of risk stratification tools in patients with therapy-related vs de novo myelodysplastic syndromes: a report on behalf of the MDS Clinical Research Consortium
|
|---|---|
| Autor/in / Beteiligte Person: | List, Alan F. ; DeZern, Amy E. ; Steensma, David P. ; Lancet, J.E. ; Barnard, John ; Jabbour, E. ; Sekeres, Mikkael A. ; Garcia-Manero, G. ; Zeidan, Amer M. ; Padron, Eric ; N. Al Ali ; Roboz, Gail J. ; Komrokji, Rami S. |
| Link: | |
| Zeitschrift: | Leukemia, Jg. 31 (2017-01-23), S. 1391-1397 |
| Veröffentlichung: | Springer Science and Business Media LLC, 2017 |
| Medientyp: | unknown |
| ISSN: | 1476-5551 (print) ; 0887-6924 (print) |
| DOI: | 10.1038/leu.2017.33 |
| Schlagwort: |
|
| Sonstiges: |
|