Hif-1α and IGF Expression in Endometrial Hyperplasia
In: Journal of Education, Health and Sport, Jg. 10 (2020), Heft 11, S. 61-68
Online
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Chumak Z. V., Shapoval M. V., Andrievskiy O. G. Hif-1α and IGF Expression in Endometrial Hyperplasia. Journal of Education, Health and Sport. 2020;10(11):61-68. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.11.006 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.11.006 https://zenodo.org/record/268459 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 16.10.2020. Revised: 30.10.2020. Accepted: 11.11.2020. Hif-1α and IGF Expression in Endometrial Hyperplasia Z. V. Chumak1,2, M. V. Shapoval1, O. G. Andrievskiy1 1Odessa National Medical University; 2Сity Center for Menopause, Odessa, Ukraine Abstract The objective: to assess the effect of insulin resistance and hypoxia on the risk of endometrial hyperplasia development. The research was conducted on the base of Municipal Maternity House №5 (Odessa, Ukraine). The data obtained from the sample of 417 reproductive, perimenopausal, and postmenopausal age women who referred for medical care to the gynecological department, were analyzed. All the women under examination were carried out medical and diagnostic scraping of the uterine cavity. Results. The intensity of hypoxia increases with age and closely correlates (r=0,78) with the level of insulin resistance. IGF demonstrates reverse dynamics – its rates has been diminished with age (r=-0,63). Conclusion. It was demonstrated that insulin resistance and hypoxia play significant role in the pathogenesis of endometrial hyperplasia. Indices of IGF and HIF could be recommended as valuable biomarkers of prognosis in the case of endometrial hyperplasia. Key words: endometrial hyperplasia; IGF; Hif-1α; malignancy
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Hif-1α and IGF Expression in Endometrial Hyperplasia
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Autor/in / Beteiligte Person: | Andrievskiy, O. G. ; Chumak, Z. V. ; Shapoval, M. V. |
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Zeitschrift: | Journal of Education, Health and Sport, Jg. 10 (2020), Heft 11, S. 61-68 |
Veröffentlichung: | Kazimierz Wielki University, 2020 |
Medientyp: | unknown |
ISSN: | 2391-8306 (print) |
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